Archives des mots-clés : biomedical research

Attitudes Toward Providing Open Access for Use of Biospecimens and Health Records: A Cross-Sectional Study from Jordan

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Authors : Kamal M Al-Shami, Wesam S Ahmed, Karem H Alzoubi

Purpose

Biospecimen repositories and big data generated from clinical research are critically important in advancing patient-centered healthcare. However, ethical considerations arising from reusing clinical samples and health records for subsequent research pose a hurdle for big-data health research. This study aims to assess the public’s opinions in Jordan toward providing blanket consent for using biospecimens and health records in research.

Participants and Methods

A cross-sectional study utilizing a self-reported questionnaire was carried out in different cities in Jordan, targeting adult participants. Outcome variables included awareness of clinical research, participation in clinical research, and opinions toward providing open access to clinical samples and records for research purposes.

Descriptive analysis was utilized for reporting the outcome as frequency (percentages) out of the total responses. Univariate and multivariate logistic regression were used to investigate the association between independent variables and the outcome of interest.

Results

A total of 1033 eligible participants completed the questionnaire. Although the majority (90%) were aware of clinical research, only 24% have ever participated in this type of research. About half (51%) agreed on providing blanket consent for the use of clinical samples, while a lower percentage (43%) agreed on providing open access to their health records.

Privacy concerns and lack of trust in the researcher were cited as major barriers to providing blanket consent. Participation in clinical research and having health insurance were predictors for providing open access to clinical samples and records.

Conclusion

The lack of public trust in Jordan toward data privacy is evident from this study. Therefore, a governance framework is needed to raise and maintain the public’s trust in big-data research that warrants the future reuse of clinical samples and records. As such, the current study provides valuable insights that will inform the design of effective consent protocols required in data-intensive health research.

URL : Attitudes Toward Providing Open Access for Use of Biospecimens and Health Records: A Cross-Sectional Study from Jordan

DOI : https://doi.org/10.2147/PPA.S402769

Hybrid Gold Open Access Citation Advantage in Clinical Medicine: Analysis of Hybrid Journals in the Web of Science

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Authors : Chompunuch Saravudecha, Duangruthai Na Thungfai, Chananthida Phasom, Sodsri Gunta-in, Aorrakanya Metha, Peangkobfah Punyaphet, Tippawan Sookruay, Wannachai Sakuludomkan, Nut Koonrungsesomboon

Biomedical fields have seen a remarkable increase in hybrid Gold open access articles. However, it is uncertain whether the hybrid Gold open access option contributes to a citation advantage, an increase in the citations of articles made immediately available as open access regardless of the article’s quality or whether it involves a trending topic of discussion.

This study aimed to compare the citation counts of hybrid Gold open access articles to subscription articles published in hybrid journals. The study aimed to ascertain if hybrid Gold open access publications yield an advantage in terms of citations.

This cross-sectional study included the list of hybrid journals under 59 categories in the ‘Clinical Medicine’ group from Clarivate’s Journal Citation Reports (JCR) during 2018–2021. The number of citable items with ‘Gold Open Access’ and ‘Subscription and Free to Read’ in each journal, as well as the number of citations of those citable items, were extracted from JCR.

A hybrid Gold open access citation advantage was computed by dividing the number of citations per citable item with hybrid Gold open access by the number of citations per citable item with a subscription.

A total of 498, 636, 1009, and 1328 hybrid journals in the 2018 JCR, 2019 JCR, 2020 JCR, and 2021 JCR, respectively, were included in this study. The citation advantage of hybrid Gold open access articles over subscription articles in 2018 was 1.45 (95% confidence interval (CI), 1.24–1.65); in 2019, it was 1.31 (95% CI, 1.20–1.41); in 2020, it was 1.30 (95% CI, 1.20–1.39); and in 2021, it was 1.31 (95% CI, 1.20–1.42).

In the ‘Clinical Medicine’ discipline, the articles published in the hybrid journal as hybrid Gold open access had a greater number of citations when compared to those published as a subscription, self-archived, or otherwise openly accessible option.

URL : Hybrid Gold Open Access Citation Advantage in Clinical Medicine: Analysis of Hybrid Journals in the Web of Science

DOI : https://doi.org/10.3390/publications11020021

PreprintMatch: A tool for preprint to publication detection shows global inequities in scientific publication

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Authors : Peter Eckmann, Anita Bandrowski

Preprints, versions of scientific manuscripts that precede peer review, are growing in popularity. They offer an opportunity to democratize and accelerate research, as they have no publication costs or a lengthy peer review process. Preprints are often later published in peer-reviewed venues, but these publications and the original preprints are frequently not linked in any way.

To this end, we developed a tool, PreprintMatch, to find matches between preprints and their corresponding published papers, if they exist. This tool outperforms existing techniques to match preprints and papers, both on matching performance and speed. PreprintMatch was applied to search for matches between preprints (from bioRxiv and medRxiv), and PubMed.

The preliminary nature of preprints offers a unique perspective into scientific projects at a relatively early stage, and with better matching between preprint and paper, we explored questions related to research inequity.

We found that preprints from low income countries are published as peer-reviewed papers at a lower rate than high income countries (39.6% and 61.1%, respectively), and our data is consistent with previous work that cite a lack of resources, lack of stability, and policy choices to explain this discrepancy.

Preprints from low income countries were also found to be published quicker (178 vs 203 days) and with less title, abstract, and author similarity to the published version compared to high income countries. Low income countries add more authors from the preprint to the published version than high income countries (0.42 authors vs 0.32, respectively), a practice that is significantly more frequent in China compared to similar countries.

Finally, we find that some publishers publish work with authors from lower income countries more frequently than others.

URL : PreprintMatch: A tool for preprint to publication detection shows global inequities in scientific publication

DOI : https://doi.org/10.1371/journal.pone.0281659

Investigation of potential gender bias in the peer review system at Reproduction

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Authors : Marie Biolková, Tom Moore, Karen Schindler, Karl Swann, Andy Vail, Lindsay Flook, Helen Dick, Greg Fitzharris, Christopher A. Price, Norah Spears

This study examined whether publication outcome was affected by the gender of author, handling associate editor (AE), or reviewer, and whether there was gender bias in reviewer selection, in the journal Reproduction.

Analyses were carried out on 4289 original research manuscripts submitted to the journal between 2007 and 2019. Both female and male AEs appointed more male reviewers than female reviewers, but female AEs were significantly more likely to appoint female reviewers than male AEs were (p < 0.001).

When examining the gender of either first or last author manuscripts, those with female authors that were reviewed by female reviewers received better scores than those with male authors that were reviewed by female reviewers (p < 0.05): where the reviewer was male, no such effect was observed.

Acceptance rates of manuscripts were similar for both female and male authors, whether first or last, regardless of AE gender. Overall, there was no significant correlation between gender of first or last author, or of AE, on the likelihood of acceptance of a research paper.

These data suggest no bias against female authors during the peer review process in this reproductive biology journal.

URL : Investigation of potential gender bias in the peer review system at Reproduction

DOI : https://doi.org/10.1002/leap.1537

Leveraging Open Tools to Realize the Potential of Self-Archiving: A Cohort Study in Clinical Trials

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Author : Delwen L. Franzen

While open access (OA) is growing, many publications remain behind a paywall. This limits the impact of research and entrenches global inequalities by restricting access to knowledge to those that can afford it.

Many journal policies allow researchers to make a version of their publication openly accessible through self-archiving in a repository, sometimes after an embargo period (green OA). Unpaywall and Shareyourpaper are open tools that help users find OA articles and support authors to legally self-archive their papers, respectively.

This study leveraged these tools to assess the potential of green OA to increase discoverability in a cohort of clinical trial results publications from German university medical centers. Of the 1897 publications in this cohort, 46% (n = 871/1897, 95% confidence interval (CI) 44% to 48%) were neither openly accessible via a journal or a repository. Of these, 85% (n = 736/871, 95% CI 82% to 87%) had a permission to self-archive the accepted or published version in an institutional repository.

Thus, most of the closed-access clinical trial results in this cohort could be made openly accessible in a repository, in line with World Health Organization (WHO) recommendations.

In addition to providing further evidence of the unrealized potential of green OA, this study demonstrates the use of open tools to obtain actionable information on self-archiving at scale and empowers efforts to increase science discoverability.

URL : Leveraging Open Tools to Realize the Potential of Self-Archiving: A Cohort Study in Clinical Trials

DOI : https://doi.org/10.3390/publications11010004

Do open-access dermatology articles have higher citation counts than those with subscription-based access?

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Authors : Fangyi Xie, Sherief Ghozy, David F. Kallmes, Julia S. Lehman

Background

Open-access (OA) publishing is increasingly prevalent in dermatology, and many journals now offer hybrid options, including conventional (subscription-based access [SA]) publishing or OA (with an author publishing charge) in a subscription journal. OA publishing has been noted in many disciplines, but this has been rarely studied in dermatology.

Methods

Using the Clarivate Journal Citation Report, we compiled a list of English-language dermatology hybrid OA journals containing more than 5% OA articles. We sampled any OA review or original research article in 4 issues from 2018 to 2019 and matched an equal number of SA articles. Citation count, citation count excluding self-citations and view counts found using Scopus and Altmetrics score were recorded for each article. Statistical analyses were performed using logistic and negative binomial models using R software.

Results

Twenty-seven hybrid dermatology journals were found, and 538 articles were sampled (269 OA, 269 SA). For both original research and review articles, OA articles had significantly higher mean citation counts (mean 13.2, standard deviation [SD] 17.0) compared to SA articles (mean 7.9, SD 8.8) (odds ratio [OR] 1.04; 95% CI 1.02–1.05; P < .001) including when adjusted for time from publication.

Original research OA articles had significantly higher citation counts than original research SA articles (excluding self-citations; OR, 1.03; 95% CI, 1.01–1.05; P = .003), and review articles also had OA citation advantage than review SA articles (OR, 1.06; 95% CI, 1.02–1.11; P = .008). There was, however, no significant difference in citation counts between review articles and original research articles (OR, 1.00; 95% CI, 0.19–5.31; P = 1.000).

There was no significant difference seen in view counts (OA: mean±SD 17.7±10.8; SA: mean±SD 17.1±12.4) and Altmetric score (OA: mean±SD 13.2±47.8; SA: mean±SD 6.3±25.0) between OA and SA articles. Potential confounders included the fact that more OA articles were published in Europe than in Asia, and pharmaceutical-funded articles were more likely to be published OA.

Conclusions

We noted a higher citation count for OA articles than SA articles in dermatology hybrid journals. However, dermatology researchers should take into account confounding factors when deciding whether to increase the impact of their work by selecting OA over SA publishing.

URL : Do open-access dermatology articles have higher citation counts than those with subscription-based access?

DOI : https://doi.org/10.1371/journal.pone.0279265

The Preprint Club – A cross-institutional, community-based approach to peer reviewing

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Authors : Felix Clemens Richter, Ester Gea-Mallorquí, Nicolas Ruffin, Nicolas Vabret

The academic community has been increasingly using preprints to disseminate their latest research findings quickly and openly. This early and open access of non-peer reviewed research warrants new means from the scientific community to efficiently assess and provide feedback to preprints. Yet, most peer review of scientific studies performed today are still managed by journals, each having their own peer review policy and transparency.

However, approaches to uncouple the peer review process from journal publication are emerging. Additionally, formal education of early career researchers (ECRs) in peer reviewing is rarely available, hampering the quality of peer review feedback.

Here, we introduce the Preprint Club, a cross-institutional, community-based approach to peer reviewing, founded by ECRs from the University of Oxford, Karolinska Institutet and Icahn School of Medicine at Mount Sinai.

Over the past two years and using the collaborative setting of the Preprint Club, we have been discussing, assessing, and providing feedback on recent preprints in the field of immunology.

In this article, we provide a blueprint of the Preprint Club basic structure, demonstrate its effectiveness, and detail the lessons we learned on its impact on peer review training and preprint author’s perception.

DOI : https://doi.org/10.1101/2023.01.04.522570