Catégories
EN

Open access chemical probes for epigenetic targets

Background

High attrition rates in drug discovery call for new approaches to improve target validation. Academia is filling gaps, but often lacks the experience and resources of the pharmaceutical industry resulting in poorly characterized tool compounds.

Discussion

The SGC has established an open access chemical probe consortium, currently encompassing ten pharmaceutical companies. One of its mandates is to create well-characterized inhibitors (chemical probes) for epigenetic targets to enable new biology and target validation for drug development.

Conclusion

Epigenetic probe compounds have proven to be very valuable and have not only spurred a plethora of novel biological findings, but also provided starting points for clinical trials. These probes have proven to be critical complementation to traditional genetic targeting strategies and provided sometimes surprising results.

URL : http://www.future-science.com/doi/pdfplus/10.4155/fmc.15.127

Catégories
EN

Institutional policy implementation at University of Minho, Portugal

This case study describes the implementation process of the Open Access institutional policy at the University of Minho (UMinho), Portugal. Starting with a brief introduction about the institution, in terms of its academic community and research, the document then provides a detailed description of the steps taken to implement the UMinho’s institutional repository (the IR) and the Open Access policy. We highlight the main goals which oriented the implementation of the repository, the devised communication plan, the value-added services created for authors, and finally, the engagement within the international community in these areas.

Regarding the Open Access policy, we present a brief summary of the main points of the self-archiving policy, approved late 2004, and also point out the main additions to the policy when it was upgraded in 2011.
This case study also provides some figures and tables about the results of the various monitoring processes carried out by the University of Minho Documentation Services to follow-up and measure policy compliance.
In summary, since the beginning of 2004 with the IR implementation, several initiatives have been taking place with the purpose of increasing the number of deposited documents. The Open Access policy adoption was, definitely, the main success factor amongst all the other initiatives and efforts.

URL : Institutional policy implementation at University of Minho, Portugal

Alternative location : http://www.pasteur4oa.eu/sites/pasteur4oa/files/resource/Case%20Study_UMinho.pdf

Catégories
FR

Estimation des dépenses de publication de l’Inra dans un modèle théorique « Gold Open Access »

L’étude publiée ici est le résultat d’une simulation menée à l’Institut national de la recherche agronomique (Inra) et dont l’objectif principal était de déterminer quels auraient été les coûts de diffusion en libre accès des articles publiés par ses équipes de recherche sur l’année 2011 selon un modèle Gold Open Access (ou « voie dorée ») dans lequel le financement est assuré par les auteurs et leurs établissements.

Les auteurs de l’étude comparent ensuite ces résultats avec les coûts en abonnements supportés par l’Inra. À l’instar des estimations récentes de Wouter Gerritsma (Wageningen UR Library) au sujet de ce que coûterait le passage intégral au Gold Open Access aux Pays-Bas (wowter.net/2014/03/05/costsgoing-gold-netherlands), la publication de ces résultats a pour objectif d’alimenter la réflexion collective sur l’opportunité de s’orienter vers ce nouveau modèle de diffusion.

URL : https://hal.archives-ouvertes.fr/hal-01097171/

Catégories
EN

The Future of Institutional Repositories at Small Academic Institutions: Analysis and Insights

Institutional repositories (IRs) established at universities and academic libraries over a decade ago, large and small, have encountered challenges along the way in keeping faith with their original objective: to collect, preserve, and disseminate the intellectual output of an institution in digital form. While all institutional repositories have experienced the same obstacles relating to a lack of faculty participation, those at small universities face unique challenges.

This article examines causes of low faculty contribution to IR content growth, particularly at small academic institutions. It also offers a first-hand account of building and developing an institutional repository at a small university. The article concludes by suggesting how institutional repositories at small academic institutions can thrive by focusing on classroom teaching and student experiential learning, strategic priorities of their parent institutions.

URL : http://www.dlib.org/dlib/september15/wu/09wu.html

Catégories
EN

The presence of High-impact factor Open Access Journals in Science, Technology, Engineering and Medicine (STEM) disciplines

The present study means to establish to what extent high-quality open access journals are available as an outlet for publication, by examining their distribution in different scientific disciplines, including the distribution of those journals without article processing charges.

The study is based on a systematic comparison between the journals included in the DOAJ, and the journals indexed in the Journal Citation Reports (JCR) Science edition 2013, released by Thomson Reuters.

The impact factor of Open Access (OA) journals was lower than those of other journals by a small but statistically significant amount. Open access journals are present in the upper quartile (by impact factor) of 85 out of 176 (48.8%) categories examined. There were no OA journals with an Impact Factor in only 16 categories (9%).

URL : The presence of High-impact factor Open Access Journals in Science, Technology, Engineering and Medicine (STEM) disciplines

Alternative location : http://leo.cineca.it/index.php/jlis/article/view/11257

Catégories
EN

E-thesis repositories in the world: A critical analysis

The advent of Information Communication & Technology (ICT) has resulted into a revolution in the ways of production, dissemination, preservation and accessibility of information. Traditional librarianship has opened its doors and embraced ICT to enhance and improve the quality and quantity of services provided by libraries. Libraries have expanded their scope to Library & Information Centres. With the changing trends of libraries, the users have also moved to advanced stages of accessing the information.

Theses and dissertations are one of the major sources of authentic in-depth information on a particular topic on which a researcher conducts extensive research work. In spite of being a main source of scholarly communication, the print theses and dissertations is mostly not accessible to outside world. In this way, the important information remains unused and unknown to users. The Electronic format of the theses and dissertations makes it possible for the information content to be used by information seekers.

‘Open Access’ is a boon for the users who strive for information. Policy Guidelines framed by National and International Organizations like UNESCO, BOAI, Berlin Declaration, ECHO Charter, Bethesda Statement, Salvador Declaration, National Open Access Policy and National Knowledge Commission‟s Report on Open Access (India) have promoted the benefits of open access for researchers, organizations, public and funding organizations.

Institutional repositories provide access to various institutional documents through open access. The type of contents vary from books, journals, conference proceedings, theses, dissertations, newspaper clippings, datasets, manuscripts, software, lectures, learning objects, maps, pre-prints, post-prints, research reports, audio-visual material etc.

The present research work deals with the Electronic Thesis Repositories which are a major form of grey literature of any organization. There are various benefits of ETDs like they help in increasing the citation count of the author and the institution, minimum time required for dissemination of scholarly information, various file formats can be incorporated in the electronic form which is not possible in the print theses and dissertations and they provide a solution of long term preservation of theses and dissertations. In spite of the benefits of ETDs, authors hesitate in depositing their research work in electronic format mainly due to fear of plagiarism.

There are various concepts in the whole process of setting up of an ETD Program. The present research work aims to study the various concepts of ETDs by analyzing the E-thesis Repositories in the world and collecting data from the Repository administrators through Web Questionnaire.

URL : http://pqdtopen.proquest.com/pubnum/3715419.html

Catégories
EN

Level of Awareness of Open Access Electronic Resources by Scientists in Agricultural Research Institutes in Edo State, Nigeria

Purpose

This study was conducted to determine the level of awareness of open access electronic resources (OAER) by scientists in agricultural research institutes in Edo State, South – South geopolitical zone of Nigeria.

Methodology

Descriptive survey research design was adopted. One hundred and fifty research scientists in agricultural research institutes in Edo (70 from Rubber Research Institute of Nigeria and 80 from Nigerian Institute For Oil Palm Research) constituted the population for the study. Questionnaire was used as instrument for data collection.  Two research questions guided the study.

Findings

The result of the study showed that scientists in agricultural research institutes in Edo state are fully aware of the existence of open access electronic resources but yet have greater access to traditional library materials than electronic journals and books for their research work.

Implication

The study implies that the scientists though fully aware of existence of open access electronic resources but have challenges that compeled them to still access traditional library materials for their research work.

Recommendation

It is recommended that the management of the two agricultural research institutes in Edo State should provide functional Internet facilities for the scientists and organize regular workshops and seminars aimed at informing their scientists on the relevance and use of open access electronic resources.

URL : Level of Awareness of Open Access Electronic Resources by Scientists in Agricultural Research Institutes in Edo State, Nigeria

Alternative location : http://www.ijier.net/assets/level-of-awareness-of-open-access-electronic-resources-ijier.net-vol-3-8-11.pdf